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KMID : 0861120090130020051
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Korean Journal of Oriental Preventive Medicine
2009 Volume.13 No. 2 p.51 ~ p.64
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The Anticancer Effects and Drug Metabolic Enzyme Change by Oral Intake of Agrimonia Pilosa Ledeb
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Rhee See-Hyung
Jung Hee
Go Ho-Yeon
Choi You-Kyung
Park Jong-Hyung
Kim Ji-Hye
Ko Seong-Gyu
Jeon Chan-Yong
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Abstract
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Objective:This research aimed was to investigate the anti-tumor effect, safety, mechanism and metabolizing enzyme of Agrimonia pilosa LEDEB(APL) in female C57B/L mouse.
Methods:At first, to evaluate the anti-tumor activity of APL, we divided into four groups, normal, control, APL100(100㎎/㎏), APL150(150㎎/㎏). LLC obtained American Type Culture Collection was used. LLC had been inoculated to induce tumor. To measure the anti-tumor effect of APL, we calibrate tumor size and weight. To study for mechanism of anti-tumor in APL, we used western blotting and to know metabolizing enzyme in APL we used to real-time PCR.
Results:APL100, APL150 inhibited tumor growth after medicine injected. APL did not only induced caspase-dependent apoptosis in LLC-bearing mouse tumor. In APL100, it were decreased 72% in CYP3A11. In APL150, it were decreased 62%, 75% in CYP3A11 and MRP1a respectively.
Conclusion:These results suggests that APL has some anti-tumor effects in female C57B/L mouse tumor. APL should be careful use with other drugs related with CYP3A11 or MRP1a.
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KEYWORD
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Agrimonia pilosa LEDEB(APL), Antitumor, CYP3A11, Metabolizing Enzyme
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